Allylic C(sp3)–H arylation of olefins via ternary catalysis

The direct arylation of allylic sp3 C–H bonds via organocatalysis and photoredox catalysis

Allylic C-H alkylation of unactivated α-olefins: serial ligand catalysis resumed.

Allylic C H Alkylation of Unactivated a-Olefins: Serial Ligand Catalysis Resumed**

The palladium(0)-catalyzed alkylation reaction of allylic oxygenates has found extensive use in organic synthesis. Recent efforts, however, have focused on the development of catalytic methods to replace allylic C H bonds directly with C C bonds. The selective alkylation of normally inert C H bonds presents exciting opportunities for the development of novel methods and streamlined syntheses of...

Enantioselective α-arylation of carbonyls via Cu(I)-bisoxazoline catalysis.

The enantioselective α-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.

Catalytic intermolecular linear allylic C-H amination via heterobimetallic catalysis.

Nitrogen functionality is prevalent in synthetic and natural small molecules with significant biological activities.1 Current state-ofthe-art methods for installing nitrogen into complex organic frameworks generally proceed through oxygen.2 While these methods feature high selectivities and predictable reactivities, they lengthen synthetic sequences by requiring unproductive chemical manipulati...